abstract：:Neuraminidase (NA) inhibitors play a prime role in treating influenza. However, a variety of viruses containing mutant NAs have developed severe drug resistance towards NA inhibitors, so it is of crucial significance to solve this problem. Encouraged by urea-containing compound 12 disclosed by our lab, we designed a s...

authors： Zhao H,Jiang S,Ye Z,Zhu H,Hu B,Meng P,Hu Y,Zhang H,Wang K,Wang J,Tian Y

更新日期：2021-10-05 00:00:00

abstract：:This review stretches insight about the advancement (2011-2021) of synthesized non-heterocyclic, heterocyclic and natural occurring cyclic molecules for inflammation. While inflammation is very significant in the abolition of pathogens and other causes of soreness, a protracted inflammatory procedure takes to outcomes...

authors： Neha K,Wakode S

更新日期：2021-10-05 00:00:00

abstract：:Breast cancer is the second most leading cause of death among women. Multiple drugs have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs are the development of resistance, toxicity, selectivity problem. The other therapies like hormonal therapy, surgery, radiotherapy, and immune the...

authors： Arya GC,Kaur K,Jaitak V

更新日期：2021-10-05 00:00:00

abstract：:In this study, the quality evaluation of homemade pumpkin, pear, wild plum and cabbage vinegar produced by traditional methods was carried out using the ultraviolet (UV) spectroscopy, rheology technique and Fourier transform infrared (FTIR) spectroscopy method. The measurement of UV spectra, flow behaviours and infrar...

authors： Öztürk M

更新日期：2021-10-05 00:00:00

abstract：:Molecular dynamics simulations and DFT calculations were performed for the demonstration of the structural dynamics and vibrational feature of N-Acetyl-d-glucosamine (NAG) in solution phase. The interactions between NAG and solvent molecules were evaluated through spatial distribution function and radial distribution ...

authors： Dai Y,Wu Y,Lan H,Ning W,Chen F,Yan G,Cai K

更新日期：2021-10-05 00:00:00

abstract：:A facile, friendly and one-step hydrothermal protocol was used to synthesize nitrogen-doped carbon dots (N-CDs) by utilizing hexamethylenetetramine and ethanediamine as the carbon and nitrogen sources. It demonstrated good water solubility and fluorescence properties were stable, whether in acidic or alkaline. Quantum...

authors： Liao S,Ding Z,Wang S,Tan F,Ge Y,Cui Y,Tan N,Wang H

更新日期：2021-10-05 00:00:00

abstract：:Statins play an important role in the treatment of hyperlipidemia, but drug resistance and adverse effects greatly limits their application. To discover new lipid-lowering drugs, three different series of tetrahydroprotoberberine derivatives (THPBs) were designed and synthesized. These compounds were first tested for ...

authors： Ge H,Zhang W,Yuan K,Xue H,Cheng H,Chen W,Xie Y,Zhang J,Xu X,Yang P

更新日期：2021-10-05 00:00:00

abstract：:Herein, a multifunctional ratiometric fluorescent (RF) probe Fe-MIL-88NH2@RhB was fabricated for individual detection of Cu2+/Glu and continuous sensing of Glu based on unique coordination principle by encapsulating RhB into the porous of metal-organic-framework-Fe-MIL-88NH2. Designed Fe-MIL-88NH2@RhB platform could s...

authors： Zhang Y,Li Y,Zhang L

更新日期：2021-10-05 00:00:00

abstract：:Löfgren's syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and an accumulation of CD4+ T cells of unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen specificity and identified a peptide derived f...

authors： Greaves SA,Ravindran A,Santos RG,Chen L,Falta MT,Wang Y,Mitchell AM,Atif SM,Mack DG,Tinega AN,Maier LA,Dai S,Pinilla C,Grunewald J,Fontenot AP

更新日期：2021-10-04 00:00:00

abstract：:Understanding mechanisms of immune regulation is key to developing immunotherapies for autoimmunity and cancer. We examined the role of mononuclear phagocytes during peripheral T cell regulation in type 1 diabetes and melanoma. MERTK expression and activity in mononuclear phagocytes in the pancreatic islets promoted i...

authors： Lindsay RS,Whitesell JC,Dew KE,Rodriguez E,Sandor AM,Tracy D,Yannacone SF,Basta BN,Jacobelli J,Friedman RS

更新日期：2021-10-04 00:00:00

abstract：:The in vivo physiological function of liquid-liquid phase separation (LLPS) that governs non-membrane-bound structures remains elusive. Among LLPS-prone proteins, TAR DNA-binding protein of 43 kD (TDP-43) is under intense investigation because of its close association with neurological disorders. Here, we generated mi...

authors： Gao J,Wang L,Ren X,Dunn JR,Peters A,Miyagi M,Fujioka H,Zhao F,Askwith C,Liang J,Wang X

更新日期：2021-10-04 00:00:00

abstract：:Long-lasting immunity depends on the generation of protective antibodies through the germinal center (GC) reaction. N6-methyladenosine (m6A) modification of mRNAs by METTL3 activity modulates transcript lifetime primarily through the function of m6A readers; however, the physiological role of this molecular machinery ...

authors： Grenov AC,Moss L,Edelheit S,Cordiner R,Schmiedel D,Biram A,Hanna JH,Jensen TH,Schwartz S,Shulman Z

更新日期：2021-10-04 00:00:00

abstract：:The transition from traditional to truly smart dynamically adaptable manufacturing demands the adoption of a high degree of autonomy within automation systems, with resultant changes in the role of the human, in both the manufacturing and logistics functions within the factory. In the context of smart manufacturing, t...

authors： Harrison R,Vera D,Ahmad B

更新日期：2021-10-04 00:00:00

abstract：:X-ray diffraction studies of muscle have provided a wealth of information on muscle structure and physiology, and the meridian of the diffraction pattern is particularly informative. Reconditi et al. (2014. J. Physiol.https://doi.org/10.1113/jphysiol.2013.267849) performed superb experiments on changes to the M3 merid...

authors： Squire JM,Knupp C

更新日期：2021-10-04 00:00:00

abstract：:To the best of our knowledge, the effect of miR-212-3p on sex-determining region Y-box 11 (SOX11) expression has not been previously investigated and how this effect affects cell proliferation and migration in lymphoma remains unclear. The present study aimed to assess the association between microRNA-212-3p (miR-212-...

authors： Tian Y,Wang L,Zhang Y,Li L,Fei Y,Zhang X,Lin G

更新日期：2021-10-01 00:00:00

abstract：:[This retracts the article DOI: 10.3892/ol.2018.8374.]. ...

authors： Li Y,Chen H,She P,Chen T,Chen L,Yuan J,Jiang B

更新日期：2021-10-01 00:00:00

abstract：:The landscape in dentistry is changing as emerging studies continue to reveal that periodontal health impacts systemic health, and vice versa. Population studies, clinical studies, and in vitro animal studies underscore the critical importance of oral health to systemic health. These inextricable relationships come to...

authors： Kapila YL

更新日期：2021-10-01 00:00:00

abstract：Introduction:Manual wheelchair propulsion is a physically demanding task associated with upper extremity pain and pathology. Shoulder pain is reported in over 25% of pediatric manual wheelchairs users, and this number rises over the lifespan. Upper extremity biomechanics in adults has been associated with shoulder pain...

authors： Hanks MM,Leonardis JM,Schnorenberg AJ,Krzak JJ,Graf A,Vogel LC,Harris GF,Slavens BA

更新日期：2021-10-01 00:00:00

abstract：:Microcystin-LR (MC-LR) and glyphosate (GLY) have been classified as a Group 2B and Group 2A carcinogens for humans, respectively, and frequently found in aquatic ecosystems. However, data on the potential hazard of MC-LR and GLY exposure to the fish gut are relatively scarce. In the current study, a subacute toxicity ...

authors： Ding W,Shangguan Y,Zhu Y,Sultan Y,Feng Y,Zhang B,Liu Y,Ma J,Li X

更新日期：2021-10-01 00:00:00

abstract：:The interaction between prostate cancer cells and osteoblasts is essential for the development of bone metastasis. Previously, novel androgen receptor axis-targeted agents (ARATs) were approved for metastatic castration-naïve and non-metastatic castration-resistant prostate cancer (CRPC); both of which are pivotal for...

authors： Samoto M,Matsuyama H,Matsumoto H,Hirata H,Ueno K,Ozawa S,Mori J,Inoue R,Yano S,Yamamoto Y,Haginaka J,Horiyama S,Tamada K

更新日期：2021-10-01 00:00:00

abstract：:Because of hormonal and immunologic changes, there are significant changes in the oral microbiome that emerge during pregnancy. Recent evidence further suggests that there is an association between the presence of periodontal disease and a pregnancy-associated oral dysbiosis. Although this oral dysbiosis and pathogeni...

authors： Ye C,Kapila Y

更新日期：2021-10-01 00:00:00

abstract：:Silver nanomaterials (AgNMs) are broadly used and among the most studied nanomaterials. The underlying molecular mechanisms (e.g. protein and metabolite response) that precede phenotypical effects have been assessed to a much lesser extent. In this paper, we assess differentially expressed proteins (DEPs) and metaboli...

authors： Maria VL,Licha D,Scott-Fordsmand JJ,Huber CG,Amorim MJB

更新日期：2021-10-01 00:00:00

abstract：:Human papillomavirus is the most common sexually transmitted infection in the world and had been linked to both anogenital and oropharyngeal cancers. It causes nearly 100% of cervical cancers and an increasing portion of oropharyngeal cancers. The geographical burden of cervical HPV infection and associated cancers is...

authors： Scott-Wittenborn N,Fakhry C

更新日期：2021-10-01 00:00:00

abstract：:Spodoptera litura (Fabricius) is a widely distributed, highly polyphagous pest that can cause severe damage to a variety of economically important crops. Various populations have developed resistance to different classes of insecticides. In this study, we report on two indoxacarb-resistant S. litura populations, namel...

authors： Hou WT,Staehelin C,Elzaki MEA,Hafeez M,Luo YS,Wang RL

更新日期：2021-10-01 00:00:00

abstract：:Breast milk is a unique biological sample that reflects the exposure levels of both lactating mothers and infants. The exposure levels of BPA due to breast milk consumption for infants can be estimated easily, but the method to estimate the total daily intake (TDI) of lactating mothers from breast milk has not yet bee...

authors： Gao Q,Niu Y,Wang B,Liu J,Zhao Y,Zhang J,Wang Y,Shao B

更新日期：2021-10-01 00:00:00

abstract：:Verteporfin (VP) is a specific inhibitor of yes-associated protein 1 (YAP1) that suppresses tumor progression by inhibiting YAP1 expression. The present study aimed to determine the inhibitory effect of VP on osteosarcoma and the underlying mechanism of its anticancer effects. Cell viability, cell cycle and apoptosis ...

authors： Yang X,Xu Y,Jiang C,Ma Z,Jin L

更新日期：2021-10-01 00:00:00

abstract：SUMMARY:Enhancing employee well-being and creating a distinct employee experience are crucial to the success of Atrium Health. Our strategies for listening, well-being, and experience have always been deep-rooted in our culture, and the COVID-19 pandemic brought extraordinary opportunities to refresh those strategies a...

authors： Dunn J

更新日期：2021-10-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes coronavirus disease 2019. Angiotensin‑converting enzyme 2 (ACE2) is the SARS‑CoV binding site and is ubiquitously expressed in endothelial cells of several organs, with the highest levels in the cardiovascular system, kidney and lung...

authors： Xu Y,Li Y

更新日期：2021-10-01 00:00:00

abstract：...

authors： Liu F,Li R,Zhang R,He M,Zhang Y

更新日期：2021-10-01 00:00:00

abstract：INTRODUCTION:Heart failure is the final pathway for a wide spectrum of myocardial stress, including hypertension and myocardial infarction. However, the potential effects of metformin on cardiac hypertrophy are still unclear. PURPOSE:The purpose of this study was to investigate whether metformin leads to suppression o...

authors： Sunagawa Y,Shimizu K,Katayama A,Funamoto M,Shimizu K,Nurmila S,Shimizu S,Miyazaki Y,Katanasaka Y,Hasegawa K,Morimoto T

更新日期：2021-10-01 00:00:00

abstract：:Tyrosine kinase inhibitors, such as gefitinib, are currently widely used as targeted therapeutics for non‑small cell lung cancer (NSCLC). Although drug resistance has become a major obstacle to successful treatment, mechanisms underlying resistance to gefitinib remain unclear. Therefore, the present study aimed to inv...

authors： Yu B,Zheng L,Tang H,Wang W,Lin Y

更新日期：2021-10-01 00:00:00

abstract：:By exploiting anonymized travel records of patients with COVID-19, this study examines the impact of social capital on individuals' responses to control measures during the early stage of the COVID-19 pandemic in China. The empirical results show that social capital measured by social trust, media publicity of social ...

authors： Liu Q,Wen S

更新日期：2021-10-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a physiologically important gas transmitter that serves various biological functions in the body, in a manner similar to that of carbon monoxide and nitric oxide. Cystathionine‑β‑synthase, cystathionine‑γ‑lyase and cysteine transaminase/3‑mercaptopyruvate sulphotransferase are important enzym...

authors： Zhang H,Zhao H,Guo N

更新日期：2021-10-01 00:00:00

abstract：Purpose:Although there are specific laboratory tests available for the diagnosis of Covid-19 and dengue, during the present pandemic era of prioritized focus on Covid-19 assessment, there are possibilities that persons with dengue may remain undiagnosed. The present study explores the role of biochemical markers in the...

authors： Bansal H,Kumar V,Mehta R

更新日期：2021-10-01 00:00:00

abstract：:Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the Transwell cell migration data shown in Figs. 2C and D, and 4B and D, were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the c...

authors： Huang J,Shi Y,Li H,Yang M,Liu G

更新日期：2021-10-01 00:00:00

abstract：:Methane recovery from waste activated sludge (WAS) through anaerobic digestion is generally restricted by the poor degradability of WAS. Herein, a novel sludge pretreatment technology by using the calcium hypochlorite (Ca(ClO)2) in enhancing the methane production from WAS anaerobic digestion was reported. The solubil...

authors： Wu SL,Wei W,Ni BJ

更新日期：2021-10-01 00:00:00

abstract：:Previous studies have suggested that oxidative stress and autophagy results in acute kidney injury (AKI) during sepsis and microRNA (miR)‑214 serves a vital role in the protection of kidneys subjected to oxidative stress. The present study aimed to test whether the renoprotection of miR‑214 is related to autophagy in ...

authors： Sang Z,Dong S,Zhang P,Wei Y

更新日期：2021-10-01 00:00:00

abstract：:Bacillus is the classic inoculant in rice straw composting. However, there has been no in-depth study of the mechanism promoting the degradation of lignocellulose and the change of indigenous bacterial communities after Bacillus inoculation. Moreover, the stability of bacterial communities is a significant challenge i...

authors： Zhang S,Xia T,Wang J,Zhao Y,Xie X,Wei Z,Zhang X,Song C,Song X

更新日期：2021-10-01 00:00:00

abstract：:The anaerobic degradation of coal combined with straw biomass can promote the methane production. The biogas production potential and metabolic pathway were explored via the co-digestion simulation experiment of coal and corn straw. The results showed that 2 g of corn straw combined respectively with 4 g of bituminous...

authors： Guo H,Zhang M,Chen Z,Shen Y,Lv J,Xu X,Yu H

更新日期：2021-10-01 00:00:00

abstract：:Researcher's all around works on a copious technique to lessen waste production and superintend the waste management for long-term socio-economic and environmental benefits. Value-added products can be produced from municipal waste by using holistic and integrated approaches. In this review, a detail about the superio...

authors： Rajendran N,Gurunathan B,Han J,Krishna S,Ananth A,Venugopal K,Sherly Priyanka RB

更新日期：2021-10-01 00:00:00